Bold alliances aid translational work

Simple rules for making alliances work.

Corporate alliances are growing in number--by about 25% a year--and account for up to a third of revenues and value at many companies. Yet some 60% to 70% of them fail. What is going wrong? Because alliances involve interdependence between companies that may be competitors and may also have vastly different operating styles and cultures, they demand more care and handling than other business ar...

Devic disease: translational medicine at work.

Translational mechanisms at work in the cohesinopathies

Chromosome cohesion, mediated by the cohesin complex, is essential for the process of chromosome segregation. Mutations in cohesin and its regulators are associated with a group of human diseases known as the cohesinopathies. These diseases are characterized by defects in head, face, limb, and heart development, mental retardation, and poor growth. The developmental features of the diseases are...

Strong Alliances in Graphs

For any simple connected graph $G=(V,E)$, a defensive alliance is a subset $S$ of $V$ satisfying the condition that every vertex $vin S$ has at most one more neighbour in $V-S$ than it has in $S$. The minimum cardinality of any defensive alliance in $G$ is called the alliance number of $G$, denoted $a(G)$. In this paper, we introduce a new type of alliance number called $k$-strong alliance numb...

Nonlinear estimation of BOLD signals with the aid of cerebral blood volume imaging

BACKGROUND The hemodynamic balloon model describes the change in coupling from underlying neural activity to observed blood oxygen level dependent (BOLD) response. It plays an increasing important role in brain research using magnetic resonance imaging (MRI) techniques. However, changes in the BOLD signal are sensitive to the resting blood volume fraction (i.e., [Formula: see text]) associated ...